The dark side of Sjögren's syndrome: the possible pathogenic role of infections.

摘要: Purpose of review To highlight recent findings on pathogenic mechanisms and clinical associations which characterize the role infectious agents as triggers for Sjogren's syndrome development. Recent Several candidate have been identified to induce autoimmune inflammatory pathways leading appearance in setting a genetic background. This is reinforced by demonstration that patients are characterized higher prevalence seropositivity virus bacterial comparison with general population. Moreover, these may infect salivary gland epithelial cells. Stronger evidence confirmed some viruses, like Epstein-Barr, disease different demonstrated interplay. experimental studies supported adjunctive an altered buccal intestinal microbial composition chronic response Helicobacter pylori induction. Finally, latent viral infections immune system stimulation induced persistent participate lymphoproliferative evolution. Summary Different induction contributors underlying complication. Deeper knowledge involved linking help identification preventive therapeutic strategy.