Detection rate of recurrent medullary thyroid carcinoma using fluorine-18 fluorodeoxyglucose positron emission tomography: a meta-analysis.

摘要: Several studies evaluated the diagnostic performance of fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET), and tomography/computed (PET/CT) in detecting recurrent medullary thyroid carcinoma (MTC) with conflicting results. Aim our study is to meta-analyze published data about this topic. A comprehensive computer literature search PubMed/MEDLINE, Scopus, Embase databases through December 2011 regarding FDG PET or PET/CT patients suspected MTC was carried out. Pooled detection rate (DR) on a per patient-based analysis calculated measure setting. sub-analysis considering device used, serum calcitonin, carcino-embryonic antigen (CEA), calcitonin doubling time (CTDT), CEA (CEADT) values also performed. Twenty-four comprising 538 were included. DR 59 % (95 % confidence interval: 54–63 %). Heterogeneity between revealed. increased calcitonin ≥1,000 ng/L (75 %), CEA ≥5 ng/ml (69 %), CTDT <12 months (76 %), CEADT <24 months (91 %). In are associated non-optimal since 40 % remain usually unidentified. However, could modify patient management certain number because these methods often performed after negative conventional imaging studies. increases higher lower CTDT CEADT values, suggesting that be very helpful more aggressive disease.