Anticonvulsant effects of gamma surgery in a model of chronic spontaneous limbic epilepsy in rats.

摘要: Object. The management of intractable epilepsy remains a challenge, despite advances in its surgical and nonsurgical treatment. identification low-risk, low-cost therapeutic strategies that lead to improved outcome is therefore an important ongoing goal basic clinical research. Single-dose focal ionizing beam radiation delivered at necrosis- inducing subnecrotic levels was investigated for effects on seizure activity by using established model chronic recurrent spontaneous limbic seizures rats. Methods. A single 90-minute period repetitive electrical stimulation (inducing stimulus) the hippocampus rats elicited episode status epilepticus, followed 2- 4-week seizure-free period. Spontaneous developed subsequently persisted duration monitoring (2–10 months). Simultaneous computerized electroencephalography video recording were used monitor animals. After establishment seizure...