Applications of Gamma Knife Radiosurgery for Experimental Investigations in Small Animal Models

摘要: The Gamma Knife (GK) was not originally designed for experimentations in small animals. In fact, there are no compatible custom accessories or stereotactic frames on the market spatial positioning of animals GK. addition, GK is intensively used patient treatments, and consequently access research with limited. On other hand, devices specially irradiation available market. For examples, animal irradiators can be purchasable from Best Theratronics (Theratronics, 2011), Rad Source Technologies (Rad Technologies, Precision X-Ray Inc. (Precision X-Ray, 2011) Xstrahl-Gulmay Medical (Xstrahl, 2011). Compared to GK, these have following advantages: lower cost, smaller size, some shielded thus don’t require a special room, combined an imaging device that allows image immediately irradiate region interest and, if needed, repeat imaging. Then, since already exist, why use experimentations? answer should include technical as well conceptual aspects. most important benefit using related difference between conventional external radiotherapy radiosurgery (GKRS). Radiation deposition produced by multiple concentric beams allow high dose very volume. These converging ionizing radiation precise volume rapid fall-off near edges which limit adverse effects surrounding adjacent tissue.