Surface-enhanced Raman scattering (SERS) optrodes for multiplexed on-chip sensing of nile blue A and oxazine 720

摘要: The fabrication and on-chip integration of surface-enhanced Raman scattering (SERS) optrodes are presented. In the optrode configuration, both laser excitation back-scattered signal transmitted through same optical fiber. SERS-active component was fabricated self-assembly silver nanoparticles on tip fibers. application SERS to detect dyes in aqueous solution indicated a limit quantification below 1 nM, using nile blue A as molecular probe. Using optrode-integrated microfluidic chip, it possible several different from solutions sequentially injected into channel. This approach for sequential detection analytes is applicable monitoring chemical processes. narrow bandwidth vibrational information generated by allowed compositions two chemically similar be distinguished dilution chip. These results demonstrate advantages SERS-optrode microfluidics applications illustrating potential this method quantify components mixture.