Evaluation of implants coated with rhBMP‐2 using two different coating strategies: a critical‐size supraalveolar peri‐implant defect study in dogs
作者： Jaebum Lee , John F. Decker , Giuseppe Polimeni , Carlo Alberto Cortella , Michael D. Rohrer
DOI: 10.1111/J.1600-051X.2010.01557.X
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摘要: Lee J, Decker JF, Polimeni G, Cortella CA, Rohrer MD, Wozney JM, Hall Susin C, Wikesjo UME. Evaluation of implants coated with rhBMP-2 using two different coating strategies: a critical-size supraalveolar peri-implant defect study in dogs. J Clin Periodontol 2010; 37: 582–590. doi: 10.1111/j.1600-051X.2010.01557.x. Abstract Background: Implants recombinant human bone morphogenetic protein-2 (rhBMP-2) induce relevant formation but also resident remodelling. Objectives: To compare the effect fully or partially on new and remodelling. Materials Methods: Twelve, male, adult, Hound Labrador mongrel dogs were used. Critical-size, supraalveolar, defects received titanium porous oxide surface their most coronal aspect (coronal-load/six animals) by immersion entire implant an solution (soak-load/six for total 30 μg rhBMP-2/implant. All air-dried. The animals euthanized at 8 weeks histometric evaluation. Results: Clinical healing was uneventful. Supraalveolar not significantly affected application protocol. New height area averaged (± SE) 3.4 ± 0.2 versus 3.5 0.4 mm 2.6 0.4 2.5 0.7 mm2 coronal-load soak-load implants, respectively (p>0.05). corresponding density bone–implant contact (BIC) recordings 38.0 3.8%versus 34.4 5.6% 25.0 31.2 3.3% In contrast, remodelling influenced Bone outside threads 74.7 3.8% 50.8 4.1% (p<0.05); within thread 51.8 1.2% 37.8 2.9%, BIC 70.1 6.7% 43.3 3.9% (p<0.05). Conclusion: Local appears to be viable technology support local osseointegration. Coronal-load obviate without compromising formation.
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