The Deep Cortex of the Lymph Node: Morphological Variations and Functional Aspects

摘要: The lymph node has long been known to comprise a medulla radiating from its hilus and cortex located along most of periphery. This “peripheral cortex” contains folliculonodules, each consisting follicle nodule (or germinal center), separated by an extrafollicular zone (Sainte-Marie Sin 1970). is also third main component which, for about the past two decades, frequently referred as “paracortex” commonly illustrated rather uniform layer underlying entire peripheral (Gutman Weissman 1972; Goldschneider Mcgregor 1973; Cottier et al. Kearney 1974; Greaves 1978). However, such topographical concept inconsistent with earlier observations which instead reported elements diverse appearances. A review literature led us distinguish these into types: nodule-like ill-defined (Table 1). Obviously, varied terminology used designate reflected great variations in histology nodal and/or inadequate knowledge histology. Therefore, we undertook detailed study aiming clarify this component, reasons presented below, will refer “deep contrast containing folliculonodules zone. findings summarized here demonstrate that deep actually formed basic structures, have now come term units” or more simply “units,” after having “pseudofollicle” while