Localisation of CD25+ cells and MHCII+ cells in lymph nodes draining Mycobacterium avium subsp. paratuberculosis vaccination granuloma and the presence of a systemic immune response
作者： M Valheim , H.J Hasvold , A.K Storset , H.J.S Larsen , C.McL Press
DOI: 10.1016/S0034-5288(02)00071-1
关键词:
摘要: Abstract Vaccination of goat kids against paratuberculosis protects lesions and clinical disease. The systemic cellular response was studied in 3–9 weeks after vaccination. Peripheral blood cells showed increased interferon-γ production expression interleukin-2 receptor (CD25) stimulation with Mycobacterium avium subsp. antigens. lymph node draining the vaccination granuloma three a parallel group kids. In deep cortex, MHCII+ were observed surrounded by CD4+ T-cells, while follicular hypertrophy hyperplasia prominent subcapsular region along connective tissue trabecula. Comparison local immune responses revealed an inverse relationship between CD25+ T-cells cortex peripheral that up-regulate CD25 upon vitro stimulation, suggesting activated regulatory influence level circulating antigen-specific following goats.
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