Antibody-dependent cytolysis of chicken erythrocytes by an in vitro-established line of mouse peritoneal macrophages.

摘要: An in vitro-established line of mouse peritoneal macrophages (IC-21) was tested for its ability to mediate the cytolysis 51chromiun-labeled chicken erythrocytes. In presence specific antibody, but independently complement, phagocytized and lysed labeled The phagocytic process proved be functionally distinct from cytolytic reaction as demonstrated by enhanced iodoacetate, an inhibitor phagocytosis. This cell line, because effector activity antibody-dependent cell-mediated immune reactions, will useful characterizing mechanism(s) involved macrophage-mediated cytolysis.