Low-molecular-weight adiponectin is more closely associated with disease activity of rheumatoid arthritis than other adiponectin multimeric forms

摘要: Adiponectin is divided into high-molecular-weight (HMW), medium-molecular-weight (MMW), and low-molecular-weight (LMW) forms. These forms differ not only in the number of adiponectin molecules but also their biological activity. There are conflicting findings regarding role rheumatoid arthritis (RA). Moreover, few reports have described relationships between serum multimers levels RA. Therefore, we examined association total its with Two study groups were examined: 180 recently diagnosed untreated RA patients disease duration less than 1 year (RA group) 160 age- sex-matched control subjects (control group). RA-related factors, blood pressure, body mass index, glucose, complete lipid profile, measured. The each multimer significantly lower (P < 0.01). Serum total, HMW, MMW, LMW positively correlated triglycerides negatively Disease Activity Score for 28 joints (DAS28). Multivariate regression analysis showed that MMW independently associated level. was level DAS28. decreased may be activity