Chimeric peptide nucleic acids incorporating (2S,5R)-aminoethyl pipecolyl units: synthesis and DNA binding studies ☆
作者： Pravin S. Shirude , Vaijayanti A. Kumar , Krishna N. Ganesh
DOI: 10.1016/J.TETLET.2004.02.099
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摘要: Abstract The design and facile synthesis of a novel chiral six-membered PNA analogue (2 S ,5 R )-1-( N -Boc-aminoethyl)-5-(thymin-1-yl)pipecolic acid, aepip PNA, that upon incorporation into sequences effected stabilization complexes with target complementary DNA. This is the first example where six membered-PNA shown to be capable forming stable DNA further expands repertoire cyclic analogues.
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