The enigma of the major repeat sequence of Candida albicans

摘要: The major repeat sequence, discovered in the yeast Candida albicans, is a stretch of repeated DNA that occurs nine times haploid genome this opportunistic fungal pathogen and probably similar number dubliniensis. In C. albicans it constitutes 1–2% genome. Its occurrence limited to those two species. Despite its role as genomic feature, function, mode expansion size due duplication internal subunits, origin mechanism distribution throughout are not understood, although associated with chromosome translocations, length polymorphisms regulation yeast–hypha dimorphic transition. polymorphism sequence has been exploited epidemiology taxonomic studies. This review describes occurrence, use examines evidence for dynamics.