Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome

摘要: Background Increased levels of P-glycoprotein occur in some osteosarcomas. In this study we determined the relation between status and outcome patients with high-grade osteosarcoma. Methods was immunohistochemically specimens osteosarcoma extremities (stage II) from 92 who were treated surgery chemotherapy. The analyzed to length event-free survival. Results presence increased significantly associated a decreased probability remaining after diagnosis (P = 0.002). multivariate analysis, 0.001) extent tumor necrosis preoperative chemotherapy 0.04) independent predictors clinical outcome. risk adverse events substantially (rate ratio, 3.37; 95 percent confidence interval, 1.60 7.10) among P-g...