Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.
作者： Yihe Huang , Paige A. Winkler , Weinan Sun , Wei Lü , Juan Du
DOI: 10.1038/S41586-018-0558-4
关键词:
摘要: Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable, non-selective cation channel that has an essential role in diverse physiological processes such as core body …
nature.com
rcsb.org
harvard.edu参考文章(56)
Anne-Laure Perraud, Andrea Fleig, Christopher A. Dunn, Leigh Ann Bagley, Pierre Launay, Carsten Schmitz, Alexander J. Stokes, Qiqin Zhu, Maurice J. Bessman, Reinhold Penner, Jean-Pierre Kinet, Andrew M. Scharenberg, ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology Nature. ,vol. 411, pp. 595- 599 ,(2001) , 10.1038/35079100
Lucia Gregorio-Teruel, Pierluigi Valente, Beiying Liu, Gregorio Fernández-Ballester, Feng Qin, Antonio Ferrer-Montiel, The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating. Biophysical Journal. ,vol. 109, pp. 529- 541 ,(2015) , 10.1016/J.BPJ.2015.06.039
Monica J. S. Nadler, Meredith C. Hermosura, Kazunori Inabe, Anne-Laure Perraud, Qiqin Zhu, Alexander J. Stokes, Tomohiro Kurosaki, Jean-Pierre Kinet, Reinhold Penner, Andrew M. Scharenberg, Andrea Fleig, LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability Nature. ,vol. 411, pp. 590- 595 ,(2001) , 10.1038/35079092
Benjamin A Barad, Nathaniel Echols, Ray Yu-Ruei Wang, Yifan Cheng, Frank DiMaio, Paul D Adams, James S Fraser, EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy Nature Methods. ,vol. 12, pp. 943- 946 ,(2015) , 10.1038/NMETH.3541
Christian Grimm, Robert Kraft, Sophie Sauerbruch, Günter Schultz, Christian Harteneck, Molecular and functional characterization of the melastatin-related cation channel TRPM3. Journal of Biological Chemistry. ,vol. 278, pp. 21493- 21501 ,(2003) , 10.1074/JBC.M300945200
Kazuya Togashi, Yuji Hara, Tomoko Tominaga, Tomohiro Higashi, Yasunobu Konishi, Yasuo Mori, Makoto Tominaga, TRPM2 activation by cyclic ADP‐ribose at body temperature is involved in insulin secretion The EMBO Journal. ,vol. 25, pp. 1804- 1815 ,(2006) , 10.1038/SJ.EMBOJ.7601083
Balázs Tóth, Iordan Iordanov, László Csanády, None, Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 16949- 16954 ,(2014) , 10.1073/PNAS.1412449111
Rong Xia, Zhu-Zhong Mei, Hong-Ju Mao, Wei Yang, Li Dong, Helen Bradley, David J. Beech, Lin-Hua Jiang, Identification of Pore Residues Engaged in Determining Divalent Cationic Permeation in Transient Receptor Potential Melastatin Subtype Channel 2 Journal of Biological Chemistry. ,vol. 283, pp. 27426- 27432 ,(2008) , 10.1074/JBC.M801049200
Thomas Voets, Bernd Nilius, Susan Hoefs, Annemiete W. C. M. van der Kemp, Guy Droogmans, Rene J. M. Bindels, Joost G. J. Hoenderop, TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. Journal of Biological Chemistry. ,vol. 279, pp. 19- 25 ,(2004) , 10.1074/JBC.M311201200
Frank J. P. Kühn, Andreas Lückhoff, Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2. Journal of Biological Chemistry. ,vol. 279, pp. 46431- 46437 ,(2004) , 10.1074/JBC.M407263200