Bacterial elimination via the photodynamic activity of a fullerene/light-harvesting antenna molecule assembled system integrated into liposome membranes

作者: Riku Kawasaki , Daiki Antoku , Reo Ohdake , Kouta Sugikawa , Atsushi Ikeda

DOI: 10.1039/D0NA00132E

关键词:

摘要: Ease of transmission and exceptionally high mortality rates make pathogen-based infections an ongoing global threat. Herein, a facile bacterial elimination process is described which based on the photodynamic activity fullerenes composed light-harvesting antenna molecules integrated into liposome membranes. This was done to expand absorption capabilities fullerene derivatives. Efficient energy transfer from photoactivated enhanced antimicrobial without any harmful lytic against red blood cells even under irradiation.

参考文章(35)
Ivan Diamond, AntonyF. Mcdonagh, CharlesB. Wilson, StevenG. Granelli, Surl Nielsen, Richard Jaenicke, PHOTODYNAMIC THERAPY OF MALIGNANT TUMOURS The Lancet. ,vol. 300, pp. 1175- 1177 ,(1972) , 10.1016/S0140-6736(72)92596-2
Barbara A. Lindig, Michael A. J. Rodgers, A. Paul Schaap, Determination of the lifetime of singlet oxygen in water-d2 using 9,10-anthracenedipropionic acid, a water-soluble probe Journal of the American Chemical Society. ,vol. 102, pp. 5590- 5593 ,(1980) , 10.1021/JA00537A030
Atsushi Ikeda, Water-soluble fullerenes using solubilizing agents, and their applications Journal of Inclusion Phenomena and Macrocyclic Chemistry. ,vol. 77, pp. 49- 65 ,(2013) , 10.1007/S10847-013-0319-9
Jessica M. A. Blair, Mark A. Webber, Alison J. Baylay, David O. Ogbolu, Laura J. V. Piddock, Molecular mechanisms of antibiotic resistance. Nature Reviews Microbiology. ,vol. 13, pp. 42- 51 ,(2015) , 10.1038/NRMICRO3380
Jon Clardy, Michael A Fischbach, Christopher T Walsh, New antibiotics from bacterial natural products. Nature Biotechnology. ,vol. 24, pp. 1541- 1550 ,(2006) , 10.1038/NBT1266
Raymond Bonnett, Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy Chemical Society Reviews. ,vol. 24, pp. 19- 33 ,(1995) , 10.1039/CS9952400019
Virender K. Sharma, Natalie Johnson, Leslie Cizmas, Thomas J. McDonald, Hyunook Kim, A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes Chemosphere. ,vol. 150, pp. 702- 714 ,(2016) , 10.1016/J.CHEMOSPHERE.2015.12.084
Atsushi Ikeda, Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yuta Kashijima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki, Formation of β‐(1,3‐1,6)‐D‐glucan‐complexed [70]fullerene and its photodynamic activity towards macrophages Organic and Biomolecular Chemistry. ,vol. 15, pp. 1990- 1997 ,(2017) , 10.1039/C6OB02747D