Altered phagocytosis by monocytes from HLA-DR2 and DR3-positive healthy adults is Fc gamma receptor specific.

摘要: Fc gamma receptor-dependent mononuclear phagocyte system (MPS) clearance of opsonized erythrocytes is prolonged in healthy adults with the class II alloantigens HLA-DR2, DR3, or DQw1, despite normal receptor-specific ligand binding by monocytes these groups. To investigate basis for MPS dysfunction, we determined phagocytic capacity blood from 66 disease-free and analyzed data according to HLA type subjects. The demonstrate decreased phagocytosis IgG-sensitized (EA) DQw1-positive subjects compared normals without B cell (2.87 +/- 0.83 erythrocytes/monocyte vs 3.87 1.05, p less than 0.004; 3.01 0.94 0.02; 3.18 0.89 0.02, respectively). Because HLA-DR2 DQw1 are linkage disequilibrium, EA alone DQw1. Among positive only no significant decrease could be seen (3.46 0.95 = NS). determine whether differences represented an dysfunction a more generalized activity, quantitative that neuraminidase-treated (EN), which receptor independent beta-glucan mediated. No segregation EN phenotypes demonstrated (DR2, 2.68 1.30 erythrocytes/monocyte; 2.95 1.30; 2.84 1.15; others, 3.06 1.14). Our indicate individuals associated systemic lupus erythematosus other autoimmune diseases, specific receptor-mediated process. This alteration function among immunogenetically defined may contribute their predisposition disease. These also apply receptor-initiated cellular functions.