Frequency of CYP2C9 and VKORC1 gene polymorphisms and their influence on warfarin dose in Egyptian pediatric patients.

摘要: Warfarin is a widely used anticoagulant that shows high inter-individual variability in the dose needed to achieve target anticoagulation. In adults, common genetic variants cytochrome P450-2C9 (CYP2C9) and vitamin K epoxide reductase complex (VKORC1) enzymes, addition non-genetic factors, explain this variability. children, data about warfarin pharmacogenetics are limited inconsistent. CYP2C9 (*2 *3) alleles VKORC1 (C1173T G-1639A) polymorphisms were studied by multiplex real time polymerase chain reaction 41 pediatric patients who received stable maintenance dose. The allele frequency of genes was CYP2C9*2 (0.085), CYP2C9*3 (0.12), 1173T (0.52), −1639A (0.54). univariate analysis, patients’ age, weight, height significantly (p < 0.0001) associated with However, gene did not affect multivariate age found be only significant determinant daily (p = 0.045). Age most dosage preliminary study including Egyptian patients. Further studies involving larger numbers children warranted determine true impact factors on doses