Interferon Gamma potentiates the injury caused by MPP(+) on SH-SY5Y cells, which is attenuated by the nitric oxide synthases inhibition.

作者: Simoneide S. Titze-de-Almeida , Cátia Faria Lustosa , Camila Hillesheim Horst , Elaine Del Bel , Ricardo Titze-de-Almeida

DOI: 10.1007/S11064-014-1449-1

关键词:

摘要: … Neuronal tumor cell lines represented by human neuroblastoma (SH-SY5Y… Moreover, SH-SY5Y cells mimic many aspects of the … with the environmental toxin MPTP. This compound can …

参考文章(54)
Clive Bate, Sarah Kempster, Victoria Last, Alun Williams, Interferon-γ increases neuronal death in response to amyloid-β1-42 Journal of Neuroinflammation. ,vol. 3, pp. 7- 7 ,(2006) , 10.1186/1742-2094-3-7
JB Schulz, RT Matthews, BG Jenkins, RJ Ferrante, D Siwek, DR Henshaw, PB Cipolloni, P Mecocci, NW Kowall, BR Rosen, Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. The Journal of Neuroscience. ,vol. 15, pp. 8419- 8429 ,(1995) , 10.1523/JNEUROSCI.15-12-08419.1995
Tiziana Alberio, Leonardo Lopiano, Mauro Fasano, None, Cellular models to investigate biochemical pathways in Parkinson’s disease FEBS Journal. ,vol. 279, pp. 1146- 1155 ,(2012) , 10.1111/J.1742-4658.2012.08516.X
Guo-yi Li, Hong-rong Xie, Lin-sen Hu, SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease. Chinese Medical Journal. ,vol. 123, pp. 1086- 1092 ,(2010) , 10.3760/CMA.J.ISSN.0366-6999.2010.08.021
Dominic Scudiero, David T. Vistica, Michael R. Boyd, Anne Monks, Philip Skehan, Angela Pittman, Tetrazolium-based Assays for Cellular Viability: A Critical Examination of Selected Parameters Affecting Formazan Production Cancer Research. ,vol. 51, pp. 2515- 2520 ,(1991)
S. Przedborski, V. Jackson-Lewis, R. Yokoyama, T. Shibata, V. L. Dawson, T. M. Dawson, Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 4565- 4571 ,(1996) , 10.1073/PNAS.93.10.4565
Miguel A Ortiz-Ortiz, José M Morán, Rosa A González-Polo, Mireia Niso-Santano, Germán Soler, José M Bravo-San Pedro, José M Fuentes, None, Nitric Oxide-Mediated Toxicity in Paraquat-Exposed SH-SY5Y Cells: A Protective Role of 7-Nitroindazole Neurotoxicity Research. ,vol. 16, pp. 160- 173 ,(2009) , 10.1007/S12640-009-9065-6
Jörg Dötsch, Arndt Harmjanz, Holger Christiansen, Jörg Hänze, Fritz Lampert, Wolfgang Rascher, Gene expression of neuronal nitric oxide synthase and adrenomedullin in human neuroblastoma using real-time PCR International Journal of Cancer. ,vol. 88, pp. 172- 175 ,(2000) , 10.1002/1097-0215(20001015)88:2<172::AID-IJC4>3.0.CO;2-I
Mohan K. Sapru, Jonathan W. Yates, Shea Hogan, Lixin Jiang, Jeremy Halter, Martha C. Bohn, Silencing of human α-synuclein in vitro and in rat brain using lentiviral-mediated RNAi Experimental Neurology. ,vol. 198, pp. 382- 390 ,(2006) , 10.1016/J.EXPNEUROL.2005.12.024
Malú G. Tansey, Matthew S. Goldberg, Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiology of Disease. ,vol. 37, pp. 510- 518 ,(2010) , 10.1016/J.NBD.2009.11.004