Immunogenicity and antitumor activity of a liposomal MUC1 peptide‐based vaccine
作者： John Samuel , Wladyslaw A. Budzynski , Mark A. Reddish , Lei Ding , Gabrielle L. Zimmermann
DOI: 10.1002/(SICI)1097-0215(19980119)75:2<295::AID-IJC20>3.0.CO;2-B
关键词:
摘要: A human MUC1-transfected mouse mammary adenocarcinoma cell line (GZHI) was used to develop both subcutaneous and intravenous tumor models. vaccine formulation comprised of a 24 mer (human MUC1) synthetic peptide encapsulated with monophosphoryl lipid adjuvant (MPLA) in multilamellar liposomes tested for immunogenicity anti-tumor activity. low dose the MUC1 (5 microg) administered provided excellent protection mice challenge The protective antitumor activity mediated by liposome correlated anti-MUC1-specific T-cell proliferation, gamma-interferon (IFN-gamma) production IgG2a anti-MUC1 antibodies, suggesting type 1 (T1) response. In contrast, lack immunized negative control vaccines IgG1 anti-MUCI antibody formation, or no antigen-specific consistent 2 (T2) response tumor.
sci-hub.se 参考文章(23)
J. Terry Ulrich, Kent R. Myers, Monophosphoryl Lipid A as an Adjuvant Vaccine Design. ,vol. 6, pp. 495- 524 ,(1995) , 10.1007/978-1-4615-1823-5_21
James S. Goydos, Elaine Elder, Theresa L. Whiteside, Olivera J. Finn, Michael T. Lotze, A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma Journal of Surgical Research. ,vol. 63, pp. 298- 304 ,(1996) , 10.1006/JSRE.1996.0264
M.S. Lan, S.K. Batra, W.N. Qi, R.S. Metzgar, M.A. Hollingsworth, Cloning and sequencing of a human pancreatic tumor mucin cDNA. Journal of Biological Chemistry. ,vol. 265, pp. 15294- 15299 ,(1990) , 10.1016/S0021-9258(18)77255-4
Sucharita Adluri, Kenneth O. Lloyd, Govindaswami Ragupathi, Philip O. Livingston, Linda A. Graeber, Friedhelm Helling, Shengle Zhang, Augmenting the Immunogenicity of Synthetic MUC1 Peptide Vaccines in Mice Cancer Research. ,vol. 56, pp. 3315- 3319 ,(1996)
S Gendler, J Taylor-Papadimitriou, T Duhig, J Rothbard, J Burchell, A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. Journal of Biological Chemistry. ,vol. 263, pp. 12820- 12823 ,(1988) , 10.1016/S0021-9258(18)37632-4
S.J. Gendler, C.A. Lancaster, J. Taylor-Papadimitriou, T. Duhig, N. Peat, J. Burchell, L. Pemberton, E.N. Lalani, D. Wilson, Molecular cloning and expression of human Tumor-associated Polymorphic Epithelial Mucin Journal of Biological Chemistry. ,vol. 265, pp. 15286- 15293 ,(1990) , 10.1016/S0021-9258(18)77254-2
Vasso Apostolopoulos, Pei-Xiang Xing, Ian F. C. McKenzie, Murine Immune Response to Cells Transfected with Human MUC1: Immunization with Cellular and Synthetic Antigens Cancer Research. ,vol. 54, pp. 5186- 5193 ,(1994)
E.N. Lalani, F. Berdichevsky, M. Boshell, M. Shearer, D. Wilson, H. Stauss, S.J. Gendler, J. Taylor-Papadimitriou, Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity. Journal of Biological Chemistry. ,vol. 266, pp. 15420- 15426 ,(1991) , 10.1016/S0021-9258(18)98632-1
R. Bruce Acres, Mara Hareuveni, Jean-Marc Balloul, Marie-Paule Kieny, Vaccinia virus MUC1 immunization of mice: immune response and protection against the growth of murine tumors bearing the MUC1 antigen. Journal of Immunotherapy. ,vol. 14, pp. 136- 143 ,(1993) , 10.1097/00002371-199308000-00009
Rosalind A. Graham, Joy M. Burchell, Peter Beverley, Joyce Taylor-Papadimitriou, Intramuscular immunisation with MUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumour cells. International Journal of Cancer. ,vol. 65, pp. 664- 670 ,(1996) , 10.1002/(SICI)1097-0215(19960301)65:5<664::AID-IJC17>3.0.CO;2-7