Animal models of human prostate cancer: The consensus report of the new york meeting of the mouse models of human cancers consortium prostate pathology committee

摘要: Animal models, particularly mouse play a central role in the study of etiology, prevention, and treatment human prostate cancer. While tissue culture models are extremely useful understanding biology cancer, they cannot recapitulate complex cellular interactions within tumor microenvironment that key cancer initiation progression. The National Cancer Institute (NCI) Mouse Models Human Cancers Consortium convened group veterinary pathologists to review current animal make recommendations about pathologic analysis these models. More than 40 different with 439 samples were reviewed, including genetically engineered xenograft, rat, canine Numerous relevant have been developed over past 15 years, each approach has strengths weaknesses. Analysis multiple shown reactive stroma formation is present all developing invasive carcinomas. In addition, numerous genetic alterations display aggressive phenotypes characterized by sarcomatoid carcinomas metastases, which presumably histologic manifestation epithelial-mesenchymal transition. significant progress development improved already accelerated our promises enhance new approaches detection, this common malignancy.