ELEVATED ALANINE AMINOTRANSFERASE (ALT) IN BLOOD DONORS: AN ASSESSMENT OF THE MAIN ASSOCIATED CONDITIONS AND ITS RELATIONSHIP TO THE DEVELOPMENT OF HEPATITIS C

摘要: The determination of aminotranferases levels is very useful in the diagnosis hepatopathies. In recent years, an elevated serum ALT level blood donors has been associated with increased risk post-transfusion hepatitis (PTH). purpose study was to research factors a cohort voluntary and evaluate relationship between development C (HCV) infection. 166 volunteer at time their first donation were studied. All questioned about previous hepatopathies, exposure hepatitis, chemicals, use medication or drugs, sexual behaviour, contact secretions intake alcohol. Every three months, AST, ALT, alkaline phosphatase, gamma glutamyl transpeptidase, cholesterol, triglyceride glycemia are assessed over two year follow-up. thyroid hormone as well presence auto-antibodies also measured. Abdominal ultrasound performed all patients persistently AST levels. A needle biopsy liver 9 without definite diagnostic after medical investigation. anti-HCV antibodies 116 assayed again clinical evaluation. At end follow-up period (2 years later) 71 tested for antibodies. None resulted positive B markers during Of donors, 101 (87%) had Obesity alcoholism principal conditions related 91/101 (90.1%) donors. Hypertriglyceridemia, hypercholesterolemia, hypothyroidism diabetes mellitus Only 1/101 (0.9%) mild chronic active non A-G viral 3/101 (2.9%) non-specific reactive hepatitis. not detect infected HCV Brazil, including initial seronegative phase.