Histological and Immunohistochemical Features of Trichoblastoma in a Sarda Breed Sheep.

摘要: Skin tumors with adnexal differentiation are commonly reported in dogs and cats, while only anecdotal evidence is available sheep. Here we illustrate the macroscopic, histologic, immunohistochemical features of a cutaneous lesion 6-year-old female Sarda breed sheep, surgically treated for horn-like mass located left pinna. Additionally, investigate possible contribution Ovine Papillomaviruses (OaPVs). Histologically, dermis was expanded by an expansive unencapsulated multilobulated nodule composed cuboidal to spindle basaloid cells arranged variably-sized cytokeratins (CK) AE1-AE3, CK 5/6 34 beta E12, p63-positive winding cords characteristic palisade arrangement neoplastic periphery tumor. Based on these results, neoplasm diagnosed as trabecular trichoblastoma rare structures resembling papillary mesenchymal bodies. multiple enlarged sebaceous lobules clustered around dilated ducts suggestive gland hyperplasia were detected near trichoblastoma. No PV DNA found examined tissues, suggesting that ovine PVs not involved pathogenesis present skin differentiation. Further investigations efforts required elucidate prevalence this species.