作者: Qiong Lin , Wolfgang Wagner
DOI: 10.1371/JOURNAL.PGEN.1005334
关键词:
摘要: Aging is associated with highly reproducible DNA methylation (DNAm) changes, which may contribute to higher prevalence of malignant diseases in the elderly. In this study, we analyzed epigenetic aging signatures 5,621 DNAm profiles 25 cancer types from The Cancer Genome Atlas (TCGA). Overall, age-associated patterns hardly reflect chronological age patients, but they are coherently modified a non-stochastic manner, particularly at CpGs that become hypermethylated upon non-malignant tissues. This coordinated regulation can therefore be used for aberrant age-predictions, facilitate disease stratification. For example, acute myeloid leukemia (AML) age-predictions increased incidence mutations RUNX1, WT1, and IDH2, whereas TET2, TP53, PML-PARA translocation more frequent younger age-predictions. Furthermore, correlate overall survival several (such as lower grade glioma, glioblastoma multiforme, esophageal carcinoma, chromophobe renal cell cutaneous melanoma, lung squamous neuroendocrine neoplasms). conclusion, not related patient, coordinately regulated, normal aging. apparent clinical parameters cancer, indicating relevant development.