Functional Phenotype of Mice Deficient in the IL-1R Type I Gene

作者: Philip J. Morrissey , Moira Glaccum , Jacques Peschon , Charles R. Maliszewski

DOI: 10.1007/978-1-4757-2753-1_10

关键词:

摘要: Interleukin 1 (IL-1) is a cytokine that involved in the mechanism of host resistance and immune function (for review, see ref. 1). Evidence indicates IL-1 functions as proinflammatory with significant well-documented effects on innate inflammatory response (2). The biological also influence development specific response. has been long studied costimulator both B-cells T-cells adjuvant effect well documented (3–5). Thus, it believed plays central role mechanisms responses.

参考文章(40)
Dinarello Ca, The biological properties of interleukin-1. European Cytokine Network. ,vol. 5, pp. 517- 531 ,(1994)
Cheers C, Liu Z, Simpson Rj, Interaction of interleukin-6, tumour necrosis factor and interleukin-1 during Listeria infection. Immunology. ,vol. 85, pp. 562- 567 ,(1995)
Emil Skamene, Patricia A. L. Kongshavn, Maurice Landy, Genetic control of natural resistance to infection and malignancy Academic Press. ,(1980)
P J Morrissey, L Bressler, A Alpert, K Charrier, In vivo administration of IL-1 induces thymic hypoplasia and increased levels of serum corticosterone. Journal of Immunology. ,vol. 141, pp. 1456- 1463 ,(1988)
D L Pihl, P J Conlon, S G Reed, K H Grabstein, IL-1 as adjuvant. Role of T cells in the augmentation of specific antibody production by recombinant human IL-1 alpha. Journal of Immunology. ,vol. 142, pp. 3129- 3133 ,(1989)
J. Slack, C.J. McMahan, S. Waugh, K. Schooley, M.K. Spriggs, J.E. Sims, S.K. Dower, Independent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptors. Journal of Biological Chemistry. ,vol. 268, pp. 2513- 2524 ,(1993) , 10.1016/S0021-9258(18)53806-0
L Rawlinson, M.R. Edbrooke, P Woo, J Saklatvala, E Stylianou, L.A. O'Neill, Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes. Journal of Biological Chemistry. ,vol. 267, pp. 15836- 15841 ,(1992) , 10.1016/S0021-9258(19)49611-7
J Hakimi, P Ling, E R Unanue, C S Tripp, M K Gately, Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma. Journal of Immunology. ,vol. 152, pp. 1883- 1887 ,(1994)
L.M. Carruth, S. Demczuk, S.B. Mizel, Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor. Journal of Biological Chemistry. ,vol. 266, pp. 12162- 12167 ,(1991) , 10.1016/S0021-9258(18)98874-5
E R Unanue, K C Sheehan, R D Schreiber, G J Bancroft, Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice. Journal of Immunology. ,vol. 143, pp. 127- 130 ,(1989)