IL-1 as adjuvant. Role of T cells in the augmentation of specific antibody production by recombinant human IL-1 alpha.

摘要: Human rIL-1 alpha significantly enhanced splenic plaque-forming cells (PFC) to SRBC in vitro and vivo. A single i.p. injection was sufficient produce a fivefold or greater increase the generation of PFC primary response. IL-1 treatment resulted an increased production Ag-specific PFC, both vivo, combination with suboptimal doses Ag. When given dose Ag IgG response occurred. vivo carrier priming for anti-hapten response, indicating Th activity. Furthermore, T from spleens mice treated provided more help (SRBC)- hapten (TNP)- specific PFC. The enhancement by occurred even presence excess neutralizing anti-IL-2 antibody. These results suggest that may enhance cell-dependent antibody part increasing activity, mechanism action involves pathways addition induction IL-2 secretion.