The Role of IL-1 in the Immune System

摘要: Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in inflammation and host responses to infection (for reviews, see refs. 1–3). The original identification of IL-1 as endogenous pyrogen, lymphocyte-activating factor, hemopoietin-1, osteoclast-activating serves demonstrate its pleiotropic activity (4). IL-1, produced by cell types such macrophages, monocytes, synovial lining cells, induces activating endothelial lymphocytes, macrophages. Upon activation, these cells produce variety chemokines, cytokines, inflammatory mediators (5), including itself, IL-6, tumor necrosis factor-α (TNF-α), IL-8, cyclooxygenase (COX)-2; molecules cause infiltration leukocytes into sites, increase the permeability blood vessel walls, induce fever (1,2,6).