Mig-6 is a negative regulator of the epidermal growth factor receptor signal.
作者： Peter Oliver Hackel , Mikhail Gishizky , Axel Ullrich
DOI: 10.1515/BC.2001.200
关键词:
摘要: In contrast to signal generation and transmission, the mechanisms molecules that negatively regulate receptor tyrosine kinase (RTK) signaling are poorly understood. Here we characterize Mig-6 as a novel negative feedback regulator of epidermal growth factor (EGFR) potential tumor suppressor. was identified in yeast two-hybrid screen with active domain EGFR bait. Upon EGF stimulation binds involving highly acidic region between amino acids 985-995. This interaction is activity-dependent, but independent 992. overexpression results reduced activation mitogenactivated protein ERK2 response EGF, not FGF or PDGF, enhanced internalization without affecting rate degradation. The induction mRNA expression FGF, indicates existence regulatory loop. Consistent these findings, possible role suppressor indicated by Mig-6-mediated inhibition overexpression-induced transformation Rati cells.
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