Rapid, transient changes at the env locus of plasma human immunodeficiency virus type 1 populations during the emergence of protease inhibitor resistance.

摘要: Plasma human immunodeficiency virus type 1 (HIV-1) populations were genetically analyzed at their most variable locus, the envelope gene, during rapid emergence of resistance to protease inhibitor monotherapy. remained constant prior drug treatment and 2 weeks following initiation therapy, while viremia fell 10- 100-fold. Concomitant with plasma rebounds associated drug-resistant virus, marked alterations then detected env locus. population changes lasted only a few before reappearance pretreatment variants. The single inhibitors was therefore major but transient nonselected Selection for thus appears be more complex than continued replication large, random, representative sampling population. possibility that drug-privileged anatomical sites containing distinct variants and/or small effective HIV-1 size account these results is discussed.