Persistence of four related human immunodeficiency virus subtypes during the course of zidovudine therapy: relationship between virion RNA and proviral DNA.

摘要: Human immunodeficiency virus (HIV) virion RNA and proviral DNA sequences have been examined over a 1-year period in an HIV-seropositive patient, commencing with the start of zidovudine treatment. By characterizing variable V3 V4 env domains, four related but structurally discrete genotypes could be identified prior to therapy during subsequent 60-week therapy. Each subtypes showed unique pattern preservation glycosylation sites. A comparison amino acid peripheral blood mononuclear cell plasma at 0, 24, 36, 60 weeks demonstrated that did not serve as predictor structure RNA. HIV subtype 3 was most prevalent three periods studied, yet no corresponding detected. Other observed, only on transient basis. The present data are consistent model infection which different substrains coexist evolve independently within individual. Characterization may required identify properties involved disease progression; characterization will yield this information.