Merkel cell carcinoma: Do you know your guidelines?

摘要: Background Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine malignancy that exhibits clinically aggressive features and associated with poor prognosis. The incidence of MCC seems to be increasing for reasons unknown, estimated 0.32/100,000 in the United States. Methods This article will review current literature National Comprehensive Cancer Network practice guidelines treatment MCC. Results Resection negative margins remains mainstay therapy. Positive nodal disease should treated neck dissection adjuvant radiotherapy. High-risk patients undergo radiotherapy, which improves oncologic outcomes. role chemotherapy less clear currently reserved advanced-stage palliative therapy. Conclusion The pathogenesis has recently been impacted discovery Merkel polyomavirus (MCPyV). Research establish targeted immunologic therapeutic options are ongoing. © 2015 Wiley Periodicals, Inc. Head Neck, Neck 38: 647–652, 2016