Role of chronic exercise in decreasing oxidized LDL-potentiated platelet activation by enhancing platelet-derived no release and bioactivity in rats.

摘要: Abstract This study investigates how chronic exercise affects Ox-LDL mediated-platelet activation. Five-week-old male Wistar rats were assigned to either control or trained groups. Trained treadmill-trained for 10 weeks after familiarization. The following measurements taken in both and groups: plasma lipid profile, oxidation of LDL, platelet adhesiveness, aggregability, cGMP contents, platelet-NO metabolite (nitrite plus nitrate) levels, urinary 8-iso-prostaglandin F 2α (8-iso-PG ) levels. Based on those measurements, major findings this can be summarized as follows: 1) the group prolonged lag time isolated LDL subjected copper-induced vitro significantly longer than group; 2) although having higher derived-NO had lower excretion 8-iso-PGF 3) a adhesiveness aggregability productions 4) Ox-LDL-potentiated Ox-LDL-attenuated NO 5) treating with L-arginine inhibited activation Results demonstrate that amounts preformed peroxides decrease while production (which acts an antioxidant) is increased exercise. Moreover, training decreases most likely by enhancing platelet-derived release bioactivity.