Cytochrome P450 CYP1A1 enzyme activity and DNA adducts in placenta of women environmentally exposed to organochlorines.

摘要: Organochlorine compounds bioaccumulate in fishing and hunting products included the daily diet of many coastal populations. Prenatal perinatal exposure to large doses PCBs PCDFs was shown be deleterious on fetal neonatal development, but information is scarce regarding possible effects chronic low-dose exposure. This study investigates biomarkers early newborns from women exposed organochlorines through consumption species marine food chains, two remote regions province Quebec (Canada). A CYP1A1-dependent enzyme activity (EROD) DNA adducts were measured placenta samples obtained 30 living Lower-North-Shore St. Lawrence River 22 Inuit Nunavik (Arctic Quebec). These also assessed a urban center (Sept-Iles) as reference group. organochlorine determined by measuring these umbilical cord plasma. The amount bulky polycyclic aromatic hydrocarbon (PAH)-related significantly greater group than Placental EROD less (OC-related) higher For both biomarkers, smoking found an important confounding factor. associated with adduct levels when stratifying for smoking. confirms that CYP1A1 induction placental tissue constitute useful induced environmental organochlorines.