Prognostic significance of circumferential resection margin involvement following oesophagectomy for cancer and the predictive role of endoluminal ultrasonography.

摘要: The optimum multimodal treatment for oesophageal cancer, and the prognostic significance of histopathological tumour involvement circumferential resection margin (CRM+) are uncertain. aims this study were to determine CRM+ after oesophagectomy identify endosonographic (endoluminal ultrasonography (EUS)) features that predict a threatened CRM+. Two hundred sixty-nine consecutive patients underwent potentially curative (103 surgery alone, 124 neoadjuvant chemotherapy (CS) 42 chemoradiotherapy (CRTS)). Primary outcome measures disease-free survival (DFS) overall (OS). was reported in 98 (38.0%) all, 90 (62.5%) pT3 patients. Multivariate analysis pathological factors revealed: lymphovascular invasion (HR 2.087, 95% CI 1.396–3.122, P<0.0001), 1.762, 1.201–2.586, P=0.004) lymph node metastasis count 1.563, 1.018–2.400, P=0.041) be independently significantly associated with DFS. Lymphovascular 2.160, 1.432–3.259, P<0.001) 1.514, 1.000–2.292, P=0.050) also OS. revealed EUS T stage (T3 or T4, OR 24.313, 7.438–79.476, P<0.0001) use not CRTS (OR 0.116, 0.035–0.382, A positive CRM better predictor DFS OS than standard pTNM stage.