Effect of neoadjuvant chemotherapy on circumferential margin positivity and its impact on prognosis in patients with resectable oesophageal cancer.
作者： V. Sujendran , J. Wheeler , R. Baron , B. F. Warren , N. Maynard
DOI: 10.1002/BJS.5983
关键词: Surgery 、 Medicine 、 Chemotherapy 、 Cancer 、 Prospective cohort study 、 Neoadjuvant therapy 、 Carcinoma 、 In patient 、 Esophageal disease 、 Circumferential margin
摘要: Background: The significance of circumferential resection margin (CRM) involvement in oesophageal cancer surgery is controversial. This study investigated the relationship between CRM involvement, locoregional recurrence and survival, after alone or with neoadjuvant chemotherapy. Methods: Patients operated on by one surgeon at a tertiary referral centre October 1997 May 2004 were identified from prospective database. Results: Some 242 patients underwent oesophagectomy; 91 had alone, 142 chemotherapy nine chemoradiotherapy. Among histologically confirmed T3 tumours, 26 (55 per cent) 47 who compared 27 (31 88 completed two cycles (P = 0·005). Thirty-seven (42 89 negative developed recurrence, 33 (59 56 positive 0·032); median survival was 28 12 months respectively < 0·001). Cox multivariable regression analysis as an independent prognostic factor 0·006). Conclusion: A predictor overall resection. There has been significant decrease introduction chemotherapy. Copyright © 2007 British Journal Surgery Society Ltd. Published John Wiley & Sons,
vumc.nl
narcis.nl参考文章(12)
P. Quirke, M.F. Dixon, P. Durdey, N.S. Williams, Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. The Lancet. ,vol. 328, pp. 996- 999 ,(1986) , 10.1016/S0140-6736(86)92612-7
Elfriede Bollschweiler, Eva Wolfgarten, Christian Gutschow, Arnulf H. H�lscher, Demographic variations in the rising incidence of esophageal adenocarcinoma in white males. Cancer. ,vol. 92, pp. 549- 555 ,(2001) , 10.1002/1097-0142(20010801)92:3<549::AID-CNCR1354>3.0.CO;2-L
I.J Adam, I.G Martin, Pj Finan, D Johnston, M.O Mohamdee, N Scott, M.F Dixon, P Quirke, Role of circumferential margin involvement in the local recurrence of rectal cancer The Lancet. ,vol. 344, pp. 707- 711 ,(1994) , 10.1016/S0140-6736(94)92206-3
P. M. Sagar, D. Johnston, M. J. McMahon, M. F. Dixon, P. Quirke, Significance of circumferential resection margin involvement after oesophagectomy for cancer. British Journal of Surgery. ,vol. 80, pp. 1386- 1388 ,(2005) , 10.1002/BJS.1800801109
O A Khan, J J Fitzgerald, I Soomro, F D Beggs, W E Morgan, J P Duffy, Prognostic significance of circumferential resection margin involvement following oesophagectomy for cancer. British Journal of Cancer. ,vol. 88, pp. 1549- 1552 ,(2003) , 10.1038/SJ.BJC.6600931
SPL Dexter, H Sue-Ling, MJ McMahon, P Quirke, N Mapstone, IG Martin, Circumferential resection margin involvement: an independent predictor of survival following surgery for oesophageal cancer Gut. ,vol. 48, pp. 667- 670 ,(2001) , 10.1136/GUT.48.5.667
D. Alderson, S. P. Courtney, R. H. Kennedy, Radical transhiatal oesophagectomy under direct vision British Journal of Surgery. ,vol. 81, pp. 404- 407 ,(2005) , 10.1002/BJS.1800810328
William J Blot, Susan S Devesa, Robert W Kneller, Joseph F Fraumeni, Rising Incidence of Adenocarcinoma of the Esophagus and nGastric Cardia JAMA: The Journal of the American Medical Association. ,vol. 265, pp. 1287- 1289 ,(1991) , 10.1001/JAMA.1991.03460100089030
Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised controlled trial The Lancet. ,vol. 359, pp. 1727- 1733 ,(2002) , 10.1016/S0140-6736(02)08651-8
Anita AM Botterweck, Leo J Schouten, Alexander Volovics, Elisabeth Dorant, Piet A van den Brandt, Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries International Journal of Epidemiology. ,vol. 29, pp. 645- 654 ,(2000) , 10.1093/IJE/29.4.645