ハナビラタケ（Sparassis crispa）子実体由来低分子画分の担癌マウスに対する抗腫瘍作用
作者： Kyosuke Yamamoto , Yoshihiro Nishikawa , Takashi Kimura , Munehiko Dombo , Nariaki Matsuura
DOI: 10.3136/NSKKK.54.419
关键词:
摘要: 食用キノコの抗腫瘍作用に関する研究の多くはβ-グルカンに注目したものであるが，それ以外の抗腫瘍成分に着目した研究は少ない．そこで本研究では，ハナビラタケ子実体由来でβ-グルカンを含まない低分子画分（FHL）の担癌マウスに対する作用について検討した．FHLを担癌マウスに経口投与すると，腫瘍増殖が抑制された．さらに，FHLを投与した担癌マウスの脾リンパ球培養上清中のIFN-γ濃度は対照群と比して顕著に上昇していた．また，FHLは顕著でないながらもin vivo血管新生阻害作用を示した．以上より，FHLは担癌マウスのTh1免疫応答を活性化することによって抗腫瘍作用を発揮することが示唆された．また，血管新生阻害作用もFHLの抗腫瘍作用に関係している可能性が考えられた．
sci-hub.se 参考文章(13)
Yoshiyuki Kimura, Kimiye Baba, Masahiko Taniguchi, Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Research. ,vol. 22, pp. 3309- 3318 ,(2002)
Shigetoshi Mizutani, Takashi Kawai, Tatsuji Enoki, Hiroaki Sagawa, Kazuo Shimanaka, Takeshi Sakai, Ikunoshin Kato, ブナシメジ（Hypsizigus marmoreus）から分離されたテルペンの腫瘍成長抑制作用 Journal of The Japanese Society for Food Science and Technology-nippon Shokuhin Kagaku Kogaku Kaishi. ,vol. 53, pp. 55- 61 ,(2006) , 10.3136/NSKKK.53.55
Makiko Kawaguchi, Ryohei Shiomi, Kengo Tabata, Yoshiaki Kosuge, Koko Mizumachi, Jun-ichi Kurisaki, Enhancement of Th1 Immune Response in Mice by the Ingestion of Suehirotake NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI. ,vol. 51, pp. 102- 105 ,(2004) , 10.3136/NSKKK.51.102
Takeshi Takaku, Yoshiyuki Kimura, Hiromichi Okuda, Isolation of an Antitumor Compound from Agaricus blazei Murill and Its Mechanism of Action Journal of Nutrition. ,vol. 131, pp. 1409- 1413 ,(2001) , 10.1093/JN/131.5.1409
Naohito OHNO, Noriko N. MIURA, Mitsuhiro NAKAJIMA, Toshiro YADOMAE, Antitumor 1,3-β-Glucan from Cultured Fruit Body of Sparassis crispa Biological & Pharmaceutical Bulletin. ,vol. 23, pp. 866- 872 ,(2000) , 10.1248/BPB.23.866
Hiroaki Takimoto, Daiko Wakita, Kiichiro Kawaguchi, Yoshio Kumazawa, Potentiation of cytotoxic activity in naïve and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies. Biological & Pharmaceutical Bulletin. ,vol. 27, pp. 404- 406 ,(2004) , 10.1248/BPB.27.404
Naohito Ohno, Sachiko Nameda, Toshie Harada, Noriko N. Miura, Yoshiyuki Adachi, Mitsuhiro Nakajima, Kenshi Yoshida, Hitoji Yoshida, Toshiro Yadomae, Immunomodulating Activity of a b -Glucan Preparation, SCG, Extracted from a Culinary–Medicinal Mushroom, Sparassis crispa Wulf.:Fr. (Aphyllophoromycetideae), and Application to Cancer Patients International Journal of Medicinal Mushrooms. ,vol. 5, pp. 359- 368 ,(2003) , 10.1615/INTERJMEDICMUSH.V5.I4.30
Toshie Harada, Noriko Miura, Yoshiyuki Adachi, Mitsuhiro Nakajima, Toshiro Yadomae, Naohito Ohno, Effect of SCG, 1,3-β- D -Glucan from Sparassis crispa on the Hematopoietic Response in Cyclophosphamide Induced Leukopenic Mice Biological & Pharmaceutical Bulletin. ,vol. 25, pp. 931- 939 ,(2002) , 10.1248/BPB.25.931
Norie Arai, Chiyo Yoshizane, Chikako Arai, Toshiharu Hanaya, Shigeyuki Arai, Masao Ikeda, Masashi Kurimoto, Trehalose Ingestion Modifies Mucosal Immune Responses of the Small Intestine in Mice Journal of Health Science. ,vol. 48, pp. 282- 287 ,(2002) , 10.1248/JHS.48.282
Yoshiyuki Kimura, Tadashi Kido, Takeshi Takaku, Maho Sumiyoshi, Kimiye Baba, Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Science. ,vol. 95, pp. 758- 764 ,(2004) , 10.1111/J.1349-7006.2004.TB03258.X