Evidence for the involvement of the noradrenergic system, dopaminergic and imidazoline receptors in the antidepressant-like effect of tramadol in mice

摘要: The involvement of the noradrenergic system, imidazoline, dopaminergic and adenosinergic receptors in antidepressant-like action tramadol mouse forced swimming test (FST) was evaluated this study. effect (40mg/kg, per oral, p.o.) FST blocked with yohimbine (1mg/kg, i.p., an alpha(2)-adrenoceptor antagonist), alpha-methyl-para-tyrosine methyl ester (AMPT, 100mg/kg, inhibitor tyrosine hydroxylase), efaroxan imidazoline I(1)/alpha(2)-adrenoceptor idazoxan (0.06mg/kg, I(2)/alpha(2)-adrenoceptor antazoline (5mg/kg, a ligand high affinity for I(2) receptor), haloperidol (0.2mg/kg, non selective dopamine receptor SCH23390 (0.05mg/kg, subcutaneously, s.c., D(1) sulpiride (50mg/kg, D(2) D(3) antagonist) but not reversed by prazosin intraperitoneally, alpha(1)-adrenoceptor caffeine (3mg/kg, nonselective adenosine antagonist). Monoamine oxidase-A -B (MAO-A MAO-B) activities were neither inhibited whole brain nor specific regions mice treated tramadol. These data demonstrated that caused oral administration is mediated receptors.