The role of upregulated miRNAs and the identification of novel mRNA targets in prostatospheres.

摘要: TICs are characterized by their ability to self-renew, differentiate and initiate tumor formation. miRNAs small noncoding RNAs that bind mRNAs resulting in regulation of gene expression biological functions. The role cancer progression led us hypothesize may regulate genes involved TIC maintenance. Using whole genome miRNA mRNA profiling from primary prostate cells, we identified a set up-regulated down-regulated PSs. Inhibition these results decrease prostatosphere formation an increase target expression. This study uses genome-wide analyze TICs. We connect aberrant deregulated These findings can contribute better understanding the molecular mechanisms governing development/maintenance have fundamental biology