BIOCHEMICAL ASPECTS OF EGG HATCH IN ENDO- AND ECTOPARASITES : POTENTIAL FOR RATIONAL DRUG DESIGN

摘要: Control of parasites through rational drug design requires a thorough understanding the parasite's lifecycle encompassing biochemical and physiological processes which contribute to normal parasite homeostasis. The hatching eggs for example, represents an important process in development parasitic infection. Previous studies helminths have indicated that secreted enzymes often facilitate successful endoparasite egg hatch. In contrast, there are relatively few examples demonstrating role insects. An analysis this ectoparasite Lucilia cuprina suggests sheep blowfly eggs. Characterisation proteases collected at time hatch indicates presence serine proteases. Further purification characterisation these may enable specific inhibitors interfere with therefore provide novel means control.