Decreased expression of endometrial vessel AQP1 and endometrial epithelium AQP2 related to anovulatory uterine bleeding in premenopausal women.

摘要: Objective: Aquaporins (AQPs) may be involved in the occurrence of abnormal uterine bleeding as mediators between ovarian steroids and cyclic endometrial changes. The aim present study was to investigate characteristics AQPs women with anovulatory explore relationship steroids. Design: Sixty-one premenopausal 108 normal cycles were this study. Endometrial biopsies obtained from control women. Serum estradiol progesterone concentrations measured enzyme-linked immunosorbent assay on same day an biopsy performed. AQP1 AQP2 mRNA expression evaluated using reverse-transcriptase polymerase chain reaction. Immunohistochemistry used localize endometrium, their quantified by image analysis/measuring system. Results: located endothelium small vessels, whereas mainly found luminal glandular epithelium. levels protein higher secretory phase than those proliferative (P 0.05) bleeding. Conclusions: Our findings indicate that AQP1/AQP2 correlated steroid hormone essential function decreased vessels or epithelium