New animal models to probe brain tumor biology, therapy, and immunotherapy: advantages and remaining concerns.
作者： Lois A. Lampson
关键词:
摘要: New genetic models provide better biological mimics of human tumors. The new can give deeper insight into tumorigenesis and targets for testing therapies. To use the most successfully, it is useful to keep in mind limitations that are harder overcome by manipulation. These include biochemical anatomical differences between species, as well scale, both spatial temporal. Three approaches brain tumor described following articles. This essay provides a context, bringing out advantages remaining concerns. Examples taken from work immunobiology immunotherapy. complementarity different models, dichotomy general principles model-specific details stressed.
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