Prediction of Microcirculatory Oxygen Transport by Erythrocyte/Hemoglobin Solution Mixtures ☆

摘要: A mathematical model has been developed to predict oxygen transport by erythrocyte/acellular hemoglobin solution mixtures flowing in arteriolar-sized vessels (20 100 micron diameter). The includes erythrocyte and extracellular phases, radial hematocrit velocity gradients, axial convection, diffusion of both oxyhemoglobin. Model simulations were compared with experimental data from an vitro capillary where all the geometric, physical, parameters are known accurately. new approach shear augmentation 25-micron-diameter conduits was developed. Comparison theory experiment suggests that this flow regime is primarily phenomenon produced cell-cell interactions. Negligible seen suspensions plasma due relatively low solubility phase. Good agreement found between theoretical for release experiments even neglecting augmentation. However, treatment significantly improved uptake. used determine effects on varying concentration binding characteristics. It solutions more efficiently than same overall content. show erythrocyte/hemoglobin 30% virtually efficiency as pure Additional Rbc suspensions, if a high affinity.