Experimental models of non-alcoholic fatty liver disease in rats.
作者： Otto Kucera
关键词:
摘要: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic in Western world, and it persists at a high prevalence. NAFLD characterised by accumulation of triglycerides includes spectrum histopathological findings, ranging from simple through non-alcoholic steatohepatitis (NASH) to fibrosis ultimately cirrhosis, which may progress hepatocellular carcinoma. The pathogenesis closely related metabolic syndrome insulin resistance. Understanding pathophysiology treatment humans has currently been limited lack satisfactory animal models. ideal model for should reflect all aspects intricate etiopathogenesis human typical histological findings its different stages. Within past several years, great emphasis placed on development an appropriate NASH. This paper reviews widely used experimental models rats. We discuss nutritional, genetic combined their pros cons. choice suitable this while respecting limitations help improve understanding complex discover therapeutic strategies. Considering legislative, ethical, economical health factors NAFLD, are essential tools research disease.
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researchgate.net 参考文章(103)
Naga Chalasani, David W. Crabb, Oscar W. Cummings, Paul Y. Kwo, Ali Asghar, Prashant K. Pandya, Robert V. Considine, Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis The American Journal of Gastroenterology. ,vol. 98, pp. 2771- 2776 ,(2003) , 10.1111/J.1572-0241.2003.08767.X
K Soltys, Oxidative stress in fatty livers of obese Zucker rats: rapid amelioration and improved tolerance to warm ischemia with tocopherol. Hepatology. ,vol. 34, pp. 13- 18 ,(2001) , 10.1053/JHEP.2001.25452
James P. Corsetti, Janet D. Sparks, Richard G. Peterson, Robert L. Smith, Charles E. Sparks, Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats. Atherosclerosis. ,vol. 148, pp. 231- 241 ,(2000) , 10.1016/S0021-9150(99)00265-8
Brante P. Sampey, Amanda M. Vanhoose, Helena M. Winfield, Alex J. Freemerman, Michael J. Muehlbauer, Patrick T. Fueger, Christopher B. Newgard, Liza Makowski, Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High-Fat Diet Obesity. ,vol. 19, pp. 1109- 1117 ,(2011) , 10.1038/OBY.2011.18
JONG EUN YEON, KYUNG MOOK CHOI, SEI HYUN BAIK, KYOUNG OH KIM, HYOUNG JOON LIM, KI HO PARK, JIN YONG KIM, JONG-JAE PARK, JAE SEON KIM, YOUNG-TAE BAK, KWAN SOO BYUN, CHANG HONG LEE, Reduced expression of peroxisome proliferator‐activated receptor‐α may have an important role in the development of non‐alcoholic fatty liver disease Journal of Gastroenterology and Hepatology. ,vol. 19, pp. 799- 804 ,(2004) , 10.1111/J.1440-1746.2004.03349.X
Shinya Fukunishi, Hajime Nishio, Akira Fukuda, Atsushi Takeshita, Toshiaki Hanafusa, Kazuhide Higuchi, Koichi Suzuki, Development of Fibrosis in Nonalcoholic Steatosis through Combination of a Synthetic Diet Rich in Disaccharide and Low-Dose Lipopolysaccharides in the Livers of Zucker (fa/fa) Rats Journal of Clinical Biochemistry and Nutrition. ,vol. 45, pp. 322- 328 ,(2009) , 10.3164/JCBN.09-50
Perumal Nagarajan, M Jerald Mahesh Kumar, Ramasamy Venkatesan, Subeer S Majundar, Ramesh C Juyal, Genetically modified mouse models for the study of nonalcoholic fatty liver disease World Journal of Gastroenterology. ,vol. 18, pp. 1141- 1153 ,(2012) , 10.3748/WJG.V18.I11.1141
Hideto Kawaratani, Tatsuhiro Tsujimoto, Toshiyuki Kitazawa, Mitsuteru Kitade, Hitoshi Yoshiji, Masahito Uemura, Hiroshi Fukui, Innate immune reactivity of the liver in rats fed a choline- deficient L-amino-acid-defined diet World Journal of Gastroenterology. ,vol. 14, pp. 6655- 6661 ,(2008) , 10.3748/WJG.14.6655
Peter Stärkel, Christine Sempoux, Isabelle Leclercq, Michel Herin, C Deby, Jean-Pierre Desager, Yves Horsmans, Oxidative stress, KLF6 and transforming growth factor-β up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats Journal of Hepatology. ,vol. 39, pp. 538- 546 ,(2003) , 10.1016/S0168-8278(03)00360-X
Sunil K. Panchal, Hemant Poudyal, Abishek Iyer, Reeza Nazer, Ashraful Alam, Vishal Diwan, Kathleen Kauter, Conrad Sernia, Fiona Campbell, Leigh Ward, Glenda Gobe, Andrew Fenning, Lindsay Brown, High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats Journal of Cardiovascular Pharmacology. ,vol. 57, pp. 611- 624 ,(2011) , 10.1097/FJC.0B013E3181FEB90A