作者: Jette Heberg , Mette Kildevæld Simonsen , Anne Kjaergaard Danielsen , Tobias Wirenfeldt Klausen , Vibeke Zoffmann
DOI: 10.1016/J.EJON.2019.101675
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摘要: Abstract Purpose To explore separate and combined tobacco alcohol use risk of overall, smoking-related, alcohol-related, breast gynecological cancers in women. Method Questionnaires from 19,898 women The Danish Nurse Cohort 1993 were linked to registries on hospitalizations, death causes migration until Dec 2016. Cancer by was estimated using Cox proportional hazards models. Results 16,106 nurses, aged >44 years (mean = 56), eligible for analysis. Throughout 23 (mean follow-up = 18.8 years) overall counted 4,968. Of these, 1,897, 2,231, 1,407 579 events cancers. Increased risks cancer observed current smoking excess intake (>14 units/week), separately, compared never light drinking (1–7 units/week) respectively. Moderate (8–14 increased the alcohol-related cancer. Additional increases among smokers above levels (HR = 1.40, 95% CI:1.30–1.51, HR = 1.72, CI:1.52–1.94, HR = 1.33, CI:1.26–1.40, HR = 1.32, CI:1.15–1.53, respectively), non-smokers lightly. These further moderate (HR = 1.49, CI:1.36–1.63, HR = 1.97, CI:171.-2.26, HR = 1.40, CI:1.22–1.60, CI:1.12–1.57, respectively). No significant associations found Conclusions Smoking alcohol, both separately combined, cancer; resulted incremental increases. Co-use represent an extensive threat public health; thus, prevention could benefit targeting.