Review of cellular mechanotransduction on micropost substrates

摘要: As physical entities, living cells can sense and respond to various stimulations within outside the body through cellular mechanotransduction. Any deviation in mechanotransduction will not only undermine orchestrated regulation of mechanical responses, but also lead breakdown their physiological function. Therefore, a quantitative study needs be conducted both experiments computational simulations investigate underlying mechanisms In this review, we present an overview current knowledge significant progress via micropost substrates. aspect experimental studies, summarize place emphasis on coupled relationship among spreading, focal adhesion contractility as well influence substrate properties force-involved behaviors. other investigations, outline framework including biochemically motivated stress fiber model thermodynamically predicted biomechanical responses then compare simulation results with observations further explore At last, discuss future perspectives technologies models, facing challenges area