Histopathologic changes induced by the microtubule-stabilizing agent Taxol in the rat hippocampus in vivo.
作者： Octavio Mercado‐Gómez , Patricia Ferrera , Clorinda Arias , None
DOI: 10.1002/JNR.20264
关键词:
摘要: Microtubules and their associated proteins play a prominent role in neuronal morphology, axonal transport, plasticity, degeneration. It has been proposed that microtubule damage is sufficient to induce death. In this regard, the microtubule-stabilizing agent Taxol could be useful tool reproduce some aspects of neurodegenerative diseases with disturbances cytoskeleton alterations transport. Although differential effects on viability have found vitro, toxicity central nervous system remains addressed. We studied morphology as well changes microtubule-associated MAP2 tau rat hippocampus. Our results show induces dose-dependent death accompanied by loss presence dystrophic neurites. Interestingly paired helical filament (PHF)-1 immunoreactivity, which phosphorylated epitope proteins, was induced damaged suggest dynamics maintenance survival vivo, modifications dynamics, may alter content distribution promote phosphorylation state tau.
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