MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases

摘要: The contribution of microRNAs to the regulation mRNA expression during physiological and developmental processes are well-recognized. These roles being expanded by recent observations that emphasize capability miRNA participate in inter-cellular signaling communication. Several factors support a functional role for as mediators cell-to-cell signaling. able exist within extracellular milieu or circulation, their stability integrity maintained through association with binding proteins lipoproteins, encapsulation cell-derived membrane vesicles. Furthermore, can retain functionality regulate target gene following uptake recipient cells. In this overview, we review specific examples will highlight potential serve paracrine metabolic diseases cancers. Elucidating mechanisms involved communication involving provide new insights into disease pathogenesis therapeutic opportunities.