Using ex vivo proton magnetic resonance spectroscopy to reveal associations between biochemical and biological features of meningiomas.
作者： Wolfgang K. Pfisterer , Ronald A. Nieman , Adrienne C. Scheck , Stephen W. Coons , Robert F. Spetzler
DOI: 10.3171/2009.11.FOCUS09216
关键词:
摘要: Object The goal in this study was to determine if proton (1H) MR spectroscopy can differentiate meningioma grade and is associated with interpretations of biological behavior; the performed using ex vivo high-resolution spectra indicating metabolic characteristics. Methods Sixty-eight resected tissue samples meningiomas were examined 1H spectroscopy. Of these meningiomas, 46 WHO Grade I, 14 II, 8 III. Fifty-nine primary 9 recurrences. Invasion adjacent (dura mater, bone, venous sinus, brain) found 32 cases. Thirty-nine did not rapidly recur (as defined by expansion on imaging within a 5-year follow-up period), whereas rapid recurrence confirmed 24 status unknown 5 Results absolute concentrations total alanine creatine decreased high-grade compared low-grade as ratio glycine (...
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