Clinical relevance of GSTT1 mismatch in solid organ and hematopoietic stem cell transplantation.

摘要: Since 2001, year in which Glutathione S-transferase theta class 1 (GSTT1) gene appeared to be related the occurrence of de novo immune hepatitis after liver transplantation, this with two allelic variants, GSTT1(∗)A (wild type copy) and GSTT1(∗)0 (deletion copy), has emerged as a potent histocompatibility antigen. Namely, donor-recipient graft combination GSTT1-negative recipient (homozygous for GSTT1(∗)0) GSTT1-positive donor results, very frequently, appearance severe immune-related production IgG anti-GSTT1 antibodies. In kidney GSTT1 mismatch is also associated antibodies antibody-related rejection episodes C4d deposition biopsy. The more recent discovery hematopoietic stem cell clearly confirms role antigen setting. Interestingly, consequences might either or graft-versus-host disease, depending on mismatch's sense direction. involvement immunological allo-recognition unquestionable although there are still many aspects that remain explored.