Transmembrane Signaling Through Phospholipase C in Human Cortical Membranes
作者： Michael A. Wallace , Enrique Claro
DOI: 10.1007/BF01474676
关键词:
摘要: Stimulation of phosphoinositide-specific phospholipase C (PLC) by carbachol, dopamine and serotonin was measured supplying exogenous [3H]phosphatidylinositol 4,5-bisphosphate to membranes prepared from human cortex dissected frozen at autopsy. Subjects with Alzheimer's disease, Parkinson's disease or schizophrenia were compared age-matched controls no known neurological disorders. PLC the neurotransmitters dependent on presence GTPγS. Carbachol elicited greatest stimulations followed then dopamine. The maximal evoked a neurotransmitter similar for various categories subjects except in patients, where failed stimulate beyond activity attained carbachol. In sensitivity GTPγS significantly increased membranes, but not Parkinson's. Overall, experiments demonstrate feasibility using substrate assay study functionality phosphoinositide transmembrane signaling system brain.
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