Electron microscopy of non-neuronal cellular changes accompanying neural degeneration in thalamic nuclei of the rabbit. I. Reactive hematogenous and perivascular elements within the basal lamina.

摘要: Electron microscopic examination of several thalamic nuclei undergoing neural degeneration following ablation their cortical projection fields revealed reactive changes in vessels unrelated to direct mechanical trauma. A series 30 rabbits were studied at post-operative survivals one 238 days. Many neurons display signs retrograde atrophy within the first week accompanied by a distinct increase number perivascular cells basal lamina surrounding venules and large capillaries. This reaction was optimally observed between 5 98 days post-operatively limited circumscribed zones degeneration. In early stages, some displayed margination hematogenous elements, predominantly agranular leukocytes, which examples seen phases suggestive diapedesis. Cells space exhibited diverse morphology. addition indigenous “pericyte” population, there numerous few plasma eosinophils. Within second third postoperatively, elements become enlarged electron-lucent lipid vacuoles PTA-positive dense bodies complex morphology, many are clearly lysosomal nature. cellular persists for three four months, after time cytoplasm displays evidence cholesterol crystals transformations terminal or residual bodies. Morphological criteria identifying possible origin vacuolated, lysosomeladen presented consideration derivation from pericytes and/or elements. Of hypotheses considered account these findings, it appears likely that protein end-products provide stimulus aggregation subsequent transformation.